Police searching for missing teenager Alice Gross have found a body in the River Brent in west London.
Detectives hunting for the 14-year-old, who disappeared nearly five weeks ago after leaving her home in Hanwell, said there had been "significant efforts" to hide the human remains.
Scotland Yard Commander Graham McNulty said: "This is now a murder investigation and I need the public's help to find whoever is responsible."
The body has been removed from the scene and Alice's family have been informed.
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Gallery: Body Found In Major Search For Alice Gross
Police searching for missing Alice Gross have found a body in the River Brent in west London
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A cordon has been put in place after the discovery of human remains
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Forensic officers are at the scene
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Alice's family had made a heartfelt plea for the safe return of the missing teenager
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Scotland Yard released new images of Alice as police staged a reconstruction of her last known movements
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The teenager disappeared on August 28
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Police received more than a thousand calls from the public in response to appeals
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The 14-year-old has been missing for five weeks
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Police have been carrying out a fingertip search in Hanwell, west London, where missing Alice Gross is from. This image shows officers searching the area on September 22
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The hunt for the 14-year-old is the biggest search operation since the 7/7 bombings in 2005
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A dinghy was brought in to help in the search
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Here, on September 18, forensics officers are seen in the garden of builder Arnis Zalkalns
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Zalkalns, a Latvian national, has been named as the main suspect by police after he, too, went missing from his home in Boston Manor Road, which runs between Hanwell and Brentford
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September 8: a police diver enters the Grand Union Canal to search for the missing schoolgirl
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September 7: Police search the River Brent, near Hanwell
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A missing persons flyer is attached to a lamppost in central London
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She was seen on CCTV at Brentford Lock
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Arnis Zalkalns was seen on CCTV in the same area
Her father and sister have changed their Facebook profile pictures from a campaign poster to a field of wild flowers.
Mr McNulty said: "Our work at this scene is crucial to make sure we capture all of the available evidence, to establish who is responsible for this dreadful crime.
"I can confirm significant efforts were made to conceal the body."
He added: "We are unable to make a formal identification at this stage, but clearly this news is devastating for everyone involved in the search for Alice.
"At this time my thoughts are with Alice's family and friends."
Thanking the local community for their support during the investigation, he said: "This discovery will have a significant impact throughout the borough."
Alice was last seen on CCTV walking along the towpath next to the Grand Union Canal as it passes under Trumpers Way at 4.26pm on August 28. She has not been seen since.
Her disappearance sparked a huge police search - the Met's largest since the 7/7 bombings.
Hundreds of officers from several forces around the country have been involved in the investigation, while the RAF was also drafted in to help identify new search areas.
Footage from 300 CCTV cameras within a six-square-mile radius was examined, while police also staged a reconstruction of the the teenager's last-known movements in a bid to jog people's memory.
Mr McNulty said the search of the river was carried out as part of the investigation into Alice's disappearance.
Police have not said exactly where the body was found.
The River Brent runs a short distance from Hanwell and the towpath next to the Grand Union Canal where Alice was last seen on CCTV.
Convicted murderer Arnis Zalkalns, who was filmed cycling along the same route behind Alice, has emerged as the prime suspect in the case.
The Latvian builder was reported missing within days of her disappearance, but police stressed he was just "one line of enquiry".
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